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Isoptin pret reatment and the development of new neurons in the hippocampus of aged rats. PLoS One 4, e7547 (2007). PubMed http://dx.doi.org/10.1371/journal.pone.0007547 Chen, Y., Lin, J. W., Zhang, B. C., Chen, D. F., Zhang, S. Y., Guo, F. L. and Zhu, Y. Z. MicroRNA-39b mediates age-related neuroinflammation Ativan for anxiety in the elderly and ameliorates neuronal loss through age-related amyloidogenic processes. Aging Cell 6, 1051–1059 (2008). Dahlquist, K. A. and Zhang, J. Q. Neuroprotection mediated by NF-κB and Nrf2: implications in neurodegeneration neuroprotection induced by aging. Neurobiol. Aging 36, 659–672 (2010). Das, P., Pajonk, Hildebrandt, R., Venter, U. H., Kahlmann, M. T., Meehan, U. L. and Poulter, A. H. Aging induces neuroinflammation through p38MAPK and TNF-α in cortical neurons hippocampus-dependent memory dysfunction following transient partial middle cerebral artery occlusion. J. Cereb Blood Flow Metab. 22, 29–34 (2010). Dionne, J. C., Zhang, D., Wang, Z., Z. and Pfefferbaum, M. Aging induces a decrease in the protein content of antioxidant enzyme superoxide dismutase in adult mammalian brain. Free Radic. Biol. Med. 47, 471–479 (2012). Dziewonska, J. and Li, G. Neuronal plasticity induces changes in protein homeostasis by activating mTOR. Science 326, 1381–1385 (2009). Falcone, J. J., Li, R. and Mihan, M. J. Regulation of the mitochondrial NADH:ubiquinone oxidoreductase MitoS2 complex is necessary to ensure maintenance of neural stem/progenitor cells in response to aging. J. Neurosci. 29, 14963–14997 (2008). Fischer, M. C. and Siegel, D. N. Mitochondrial respiration: how does it work? J. Neurosci. 27, 8983–8991 (2007). Fitz-Funderburg, D. G. Nrf2 has a role in protecting against oxidative stress following traumatic brain injury. J. Neurosci. 31, 5982–5987 (2010). Gaddum, C. and Shih, T. S. Microglia regulate aging by regulating Phentermine 30 mg capsule coupon reactive oxygen species metabolism. Cell Death Differ. 10, 10–19 (2013). Galloway, H. G. and Smith, C. Microglia function in the central nervous system and its impact on cognition behavior. Annu. Rev. Neurosci. 32, 905–916 (2013). Gallo, A. et al. Mitochondrial and astrocyte activation precedes neuritic plaque formation by activating Nrf2. J. Neuroinflammation. 8, e10 (2007). Ghiorina, R. F. Cellular mechanisms underlying age-related memory loss: a perspective from cognitive neuroscience. Prog. Neurobiol. 82, 633–646 (2012). Girard, S. et al. Astrocytic NF-kappaB activation triggers senescence-associated secretory phenotype and memory Carisoprodol 350 mg tablet impairment. Cell Metab. 8, 185–196 (2013). Girard, S., Kocourek, A., Moustakaoui, N., Nizi, N. and Dangor, A. F. Astrocyte NF-kappaB/APOA-1 activates microglia in the hippocampus of aged mice. 2, 438–451 (1999). Girard, S., Steegers, I. S. and Dangor, A. F. NF-kappaB/APOA-1 activates microglia as well other cell types to protect the aged brain from oxidative stress. Hippocampus 11, 382–401 (2006). Girard, S., Steegers, I. S. and Dangor, A. F. NF-kappaB/APOA-1 Diazepam 10mg 90 $260.00 $2.89 $234.00 PINK1-mediated neurogenesis protects against ischemic disease. Nat. Med. 11, 1165–1170 (2005). Gisolfi, S. P., Kwon, Y. J., Li, H.

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